Complex regional pain syndrome type 1 remains a condition crying out for an organic etiology. The current reviews remain more theoretical than concrete. Because of this, we have no gold standard investigation for diagnosis. Therefore, it is impossible to accurately calculate sensitivity and specificity, as index cases are still “best guesses”. This is problematic when conducting trials on possible interventions as there is no way of determining if the patients in the trial have CRPS-1 with 100% certainty.
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